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Global and phosphoproteomics in control and TP53RK-deficient HT29 cells

ABSTRACT: We compared the global proteome and phosphoproteome between control and TP53RK-deficient HT29 cells using tandem mass tag (TMT) labeling for quantitative analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Seojin Yang

LAB HEAD: Tae-You Kim

PROVIDER: PXD061604 | Pride | 2025-10-27

REPOSITORIES: Pride

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			Action	DRS
	20200602_TP53RK_KO_GLOBAL_FN_01.raw	Raw
	20200602_TP53RK_KO_GLOBAL_FN_02.raw	Raw
	20200602_TP53RK_KO_GLOBAL_FN_03.raw	Raw
	20200602_TP53RK_KO_GLOBAL_FN_04.raw	Raw
	20200602_TP53RK_KO_GLOBAL_FN_05.raw	Raw

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Publications

Identifying TP53RK as a key regulator of colorectal cancer survival and a potential therapeutic target.

Choi Younghee Y Park Seowoo S Yang Seojin S Kim Eunju E Cho Youngwon Y Yang Hye-Ju HJ Yi Eugene C EC Song Sang-Hyun SH Kim Tae-You TY

Scientific reports 20251016 1

Colorectal cancer (CRC) is a leading cause of cancer-related mortality, necessitating the development of novel therapeutic strategies. In the present study, we identified TP53-regulating kinase (TP53RK) as a critical regulator of CRC cell survival and proliferation using a custom clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 library screen targeting serine/threonine kinase-related genes. TP53RK was significantly overexpressed in CRC tissues and wa ...[more]

PMID: 41102525

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