SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

ABSTRACT: To explore whether creatine regulates iron death sensitivity in colorectal cancer by modulating the function of certain proteins, we performed immunoprecipitation experiments with biotin-labelled creatine and conducted proteomics studies on these IP-down proteins.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: zhou xiaojun  

LAB HEAD: Li Youjun

PROVIDER: PXD061637 | Pride | 2025-09-06

REPOSITORIES: Pride