Dataset Information
Proteins interacting with Lactobacillus in the rectal epithelium of mice treated with oncolytic virus were detected
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Colon
DISEASE(S): Influenza
SUBMITTER: 
jiayu ZHANG
LAB HEAD: Jiayu Zhang
PROVIDER: PXD061642 | Pride | 2025-05-07
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| checksum.txt | Txt | |||
| identification.zip | Other | |||
| raw.zip | Other |
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Publications
Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma.
Nature communications 20250407 1
Oncolytic viruses (OVs) hold promise for cancer treatment. However, the antitumor efficacy is limited. Microbiota plays a pivotal role in cancer treatment and its impact on oncolytic virotherapy is unknown. Here, we show that VSVΔ51 has higher antitumor efficacy for hepatocellular carcinoma in the absence of microbiota in female mouse models. VSVΔ51 infection causes microbiota dysbiosis, increasing most of the gut bacteria abundance, while decreasing the commensal Lactobacillus. VSVΔ51 reduced i ...[more]
