Dataset Information

SDC4 drives fibrotic remodeling of the intervertebral disc under altered spinal loading

ABSTRACT: In this study, we study protein expression profiles in Sdc4-deleted NP cells under mechanical loading and natural physiological loading.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Nucleus Pulposus Cell Of Intervertebral Disc, Nucleus Pulposus

SUBMITTER: Kimheak Sao

LAB HEAD: Makarand V.

PROVIDER: PXD061689 | Pride | 2025-10-13

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Experimental_Details.xlsx	Xlsx
	Lab_Head_Info.xlsx	Xlsx
	Proteomic_Analysis_No_KO_Rep1.xlsx	Xlsx
	VanDeWeteringK-24-L124-KOca3-6NP1-ExplorisDIA.raw	Raw
	VanDeWeteringK-24-L124-KOca3-6NP2-ExplorisDIA.raw	Raw

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Publications

SDC4 drives fibrotic remodeling of the intervertebral disc under altered spinal loading.

Sao Kimheak K Risbud Makarand V MV

Cell death & disease 20251006 1

Alterations in physiological loading of the spine are deleterious to intervertebral disc health. The base of the mouse caudal spine region Ca3-6 that naturally experiences increased flexion, showed adaptive tissue remodeling, reminiscent of disc degeneration in young adult mice. Given the role of Syndecan 4 (SDC4), a cell surface heparan sulfate proteoglycan in disc matrix turnover and mechanosensing, we investigated if deletion could mitigate this loading-dependent phenotype. Notably, at spinal ...[more]

PMID: 41053113

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