Low-Abundance Serum Protein Biomarker Candidates for HCC in Patients with Liver Cirrhosis

ABSTRACT: In this study, we employed both untargeted and targeted analysis of low abundance serum proteins to identify potential biomarkers for HCC. We employed a two-phase proteomics approach to identify low abundance serum proteins as potential biomarkers for HCC.The first phase involved DDA-based untargeted proteomics analysis of serum samples from HCC cases and patients with CIRR. Label-free quantification (LFQ) was performed to identify statistically significantly differentially expressed proteins. In the second phase, a targeted proteomics analysis was conducted using PRM on the same cohort of samples targeting proteins selected in the untargeted study along with AFP and other previously reported biomarker candidates.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Adult Hepatocellular Carcinoma,Liver Cirrhosis

SUBMITTER: Habtom Ressom  

LAB HEAD: Habtom Ressom

PROVIDER: PXD061721 | Pride | 2026-06-15

REPOSITORIES: Pride