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Pleiotropic effects of Metformin on the chemotherapy response of HPV-positive cancer cells

ABSTRACT: Metformin has been shown to downregulate viral E6/E7 expression in HPV-positive cancer cells. However, Metformin does not induce cellular senescence, which is observed upon E6/E7 repression by RNA interference. Here we compare mass spectrometry-based proteome analyses of Metformin-treated SiHa cells (previously deposited to the ProteomeXchange Consortium with data set identifier PXC011095) with proteome analyses of SiHa cells transfected with si16E6/E7 or control siRNA (siCtrl-1) and grown for 72 hours to evaluate differences in the cell cycle regulation of HPV-positive cancer cells upon E6/E7 repression by Metformin or siE6/E7.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Cervix Carcinoma

SUBMITTER: Bianca Kuhn

LAB HEAD: Felix Hoppe-Seyler

PROVIDER: PXD061861 | Pride | 2025-06-17

REPOSITORIES: Pride

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			Action	DRS
	20201106_uniprot-proteome_homosapiens_swiss_only_BK.fasta	Fasta
	20210502_FS1_BK_21_04_F065_Mix1_Fr1.raw	Raw
	20210503_FS1_BK_21_04_F065_Mix1_Fr1.raw	Raw
	20210503_FS1_BK_21_04_F065_Mix1_Fr10.raw	Raw
	20210503_FS1_BK_21_04_F065_Mix1_Fr11.raw	Raw

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