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Derived Small Extracellular Vesicles

ABSTRACT: Epithelial ovarian cancer (OvCa) remains a leading cause of mortality among gynecological cancers. The median age of diagnosis is 63 and there exists a strong correlation between advanced age, OvCa incidence and disease stage. sEVs were analyzed using to LC-MS/MS analysis to identify and quantify sEV thier protein cargoes and were incubated with OvCa cells to evaluate their effect on pro-metastatic behaviors.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Peritoneal Cavity, Epithelial Cell

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Reihaneh Safavisohi

LAB HEAD: M Sharon

PROVIDER: PXD061884 | Pride | 2025-07-14

REPOSITORIES: Pride

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			Action	DRS
	PRIDE_db.HY_3rep.protein-peptides.csv	Csv
	RS_03172023_HY4_F3.raw	Raw

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Publications

Peritoneal cavity-derived small extracellular vesicles from aged tumor-naïve hosts promote ovarian cancer adhesion and invasion.

Safavi-Sohi Reihaneh R Johnson Jeff J Liu Yueying Y Yang Jing J Hilliard Tyvette S TS Wang Zhikun Z Barile Christopher C Mijares Josh J Wang Ceming C Chang Hsueh-Chia HC Whelan Rebecca J RJ Stack M Sharon MS

Cell communication and signaling : CCS 20250701 1

<h4>Background</h4>Epithelial ovarian cancer (OvCa) remains a leading cause of mortality among gynecological cancers. Metastasis to the peritoneum, characterized by tumor cell adhesion to and invasion of the mesothelial lining of the abdominal cavity, represents a critical early event in OvCa metastatic progression. The median age of diagnosis is 63 and there exists a strong correlation between advanced age, OvCa incidence and disease stage. Moreover, the aged peritoneal cavity represents a perm ...[more]

PMID: 40598419

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