Proteomics

Dataset Information

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Glycoproteome of CEABAC10 and C57BL6_NRj mice with and without systemic candidiasis

ABSTRACT: Co-housed young adult CEABAC10-transgenic mice (CEA) with C57BL/6NRj background and their wild type littermates (WT) were injected with 1 × 10*4 CFU C. albicans/g body weight via the lateral tail vein (Ca). Control mice received endotoxin-free buffered saline solution (PBS). Mice were sacrificed after 24 h (PBS and Ca) or 72 h (Ca). Peripheral blood was obtained via cardiac puncture. Glycoproteins were captured with hydrazide chemistry and tryptic and PNGase. F-released peptide fractions were analyzed by MS/MS. Quantitative assessment revealed differential glycoprotein expression CEABAC10 mice 72 h post-infection.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Serum

DISEASE(S): Candidiasis

SUBMITTER: Mario Müller  

LAB HEAD: Prof.Dr.Hortense Slevogt

PROVIDER: PXD061893 | Pride | 2026-05-25

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Deamidation_NSites.txt Txt
Oxidation_MSites.txt Txt
Pl_10_S2_PNG_01.raw Raw
Pl_10_S2_PNG_02.raw Raw
Pl_10_S2_TRP_01.raw Raw
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Publications

Invasive candidiasis is a fungal infection characterized by a high mortality rate. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family receptors play a crucial role in regulating innate responses of both leukocytes and epithelia. Human CEACAM3, CEACAM5 and CEACAM6 receptors recognize <i>Candida albicans</i> and are expressed in transgenic CEABAC10 mice. In a murine <i>C. albicans</i> infection model, CEABAC10 mice exhibited a shortened survival period attributed to an early c  ...[more]

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