Proteomics

Dataset Information

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Acute lymphoblastic leukemia in children produces endogenous T-cells targeting tumor associated antigens and neoantigens in peripheral blood


ABSTRACT: In this study we investigated the presence of endogenous T-cells recognizing private tumor-associated antigens and predicted neoantigens. To this end, HLA-I and HLA-II restricted tumor associated antigens (TAAs) and neoantigens were respectively identified and predicted. Of interest, circulating T-cells targeting both Mass spectrometry (MS)-identified TAAs and predicted neoantigens were identified in virtually all pediatric BCP-ALL patients, extending up to two years on remission.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Leukocyte, Bone Marrow

DISEASE(S): Acute Leukemia

SUBMITTER: Michal Bassani-Sternberg  

LAB HEAD: Michal Bassani-Sternberg

PROVIDER: PXD061914 | Pride | 2025-07-14

REPOSITORIES: Pride

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Publications

Circulating tumor-associated and neoantigen-specific endogenous T cells in children treated for B-acute lymphoblastic leukemia.

Huwiler Eliane E   Thierry Anne-Christine AC   Michaux Justine J   Pak Huisong H   Huber Florian F   Arber Caroline C   Bassani-Sternberg Michal M   Harari Alexandre A   Ceppi Francesco F  

HemaSphere 20250707 7


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