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Proteomic analysis after interference with TERC in bladder cancer cell line

ABSTRACT: Muscle-invasive bladder cancer is closely associated with the susceptibility to metastasis and poor prognosis. In recent years, numerous studies have revealed that certain long non-coding RNAs (lncRNAs) may be involved in malignant progression of tumors. Here, we identified a lncRNA, telomerase RNA component (TERC), that is significantly upregulated in invasive bladder urothelial carcinoma tissues. We used in vitro and in vivo models to demonstrate its oncogenic effects. Mechanistically, we screened out the PPAR signaling pathway (RXRA, FABP3) regulated by TERC through proteomics and enrichment analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Urinary Bladder Cancer

SUBMITTER: Chen Chen

LAB HEAD: Chen Chen

PROVIDER: PXD062013 | Pride | 2025-06-24

REPOSITORIES: Pride

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			Action	DRS
	WD005TQ01_1.raw	Raw
	WD005TQ01_10.raw	Raw
	WD005TQ01_11.raw	Raw
	WD005TQ01_12.raw	Raw
	WD005TQ01_13.raw	Raw

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