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Network-driven identification of indisulam neo-substrates for targeted protein degradation

ABSTRACT: Global proteomics discovery of Indisulam neosubstrates in HCT116

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Angelo Andres

LAB HEAD: Hua Xu

PROVIDER: PXD062148 | Pride | 2025-09-03

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	DCAF15_indisulam_Spectronaut_SEARCH_QUANT.xls.txt	Xls
	PE200_2022_GP_DCAF15_24h_DMSO_R1.raw	Raw
	PE200_2022_GP_DCAF15_24h_DMSO_R2.raw	Raw
	PE200_2022_GP_DCAF15_24h_DMSO_R3.raw	Raw
	PE200_2022_GP_DCAF15_24h_DMSO_R4.raw	Raw

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Publications

Network-driven identification of indisulam neo-substrates for targeted protein degradation.

Jarnuczak Andrew F AF Yogev Orli O Andres Angelo A Ashenden Stephanie K SK Ye Cheng C Pachl Fiona F Zhang Andrew A Cuomo Maria Emanuela ME Jin Meizhong M

Molecular omics 20251201 6

Indisulam, a DCAF15-based molecular glue degrader, induces widespread proteome changes with implications for cell division and chromosome segregation. While RBM39 and RBM23 are two well-characterized indisulam neo-substrates, additional targets likely exist. To identify those degradation targets, we applied a network-based approach to prioritize novel neo-substrates from large-scale omics data. Our approach integrates proteome-wide expression measurements with information from publicly accessibl ...[more]

PMID: 40985266

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