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Unbiased Proteomic Approach Reveals Rejuvenation-Associated Effects of Quinoa Bioester on Skin

ABSTRACT: We investigated the effects of a quinoa bioester in topical formulations on skin aging. Sixty-one female participants, one for each age between 20 and 80 years, with Fitzpatrick skin types IV or lower, underwent a 30-day treatment on the volar forearm. Skin samples were collected before and after treatment and subjected to proteomic analysis. Paired comparisons revealed an increased abundance of key proteins associated with skin health in the quinoa bioester-treated forearms; notable examples include desmoglein-1, desmocollin-1, and filaggrin which are linked to skin barrier function, antioxidative defense, and cellular turnover. To further assess the impact of quinoa bioester on skin aging, we developed a predictive model using Support Vector Regression based on the full proteomic profiles of the untreated forearms aiming to estimate the relative biological ages after treatments. Our model inferred the quinoa bioester-treated forearms as having a proteomic profile of a younger age compared to placebo-treated counterparts. Taken together, our results suggest that quinoa bioester contributes to skin health and offers potential for applications in anti-aging skincare treatments.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin

SUBMITTER: Amanda Caroline Camillo-Andrade

LAB HEAD: Paulo Costa Carvalho

PROVIDER: PXD062216 | Pride | 2026-03-16

REPOSITORIES: Pride

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			Action	DRS
	20220817_85222_Amanda_D07A_1.raw	Raw
	20220817_85222_Amanda_D07A_2.raw	Raw
	20220817_85322_Amanda_E07A_1.raw	Raw
	20220817_85322_Amanda_E07A_2.raw	Raw
	20220817_85422_Amanda_D18A_3.raw	Raw

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Project description:Aging is characterized by a gradual decline in function, partly due to molecular damage that accumulates over time. Human skin is highly susceptible to both chronological aging and environmental damage in the form of UV photoaging. This results in detrimental structural and physiological changes with age. In this study we sought to comprehensively address both chronological and photoaging at the single-cell level, and to explore genetic and environmental factors, revealing their influences on the aging process. We included samples from young, middle-aged, and old individuals, and with these samples, we compared chronological aging and photoaging. Utilizing single-cell RNA sequencing, we created a comprehensive human skin cell atlas, that offers insights into the cellular composition and functions. We investigated the renewal ability of epidermis stem cells as they age and extended the study to fibroblasts, hair follicles, and endothelial cells. Examining the genetic landscape of aging in keratinocytes, we identified two distinct "gene modules" with altered gene expression during aging. Furthermore, we uncovered that skin aging involves interactions between epidermal keratinocytes and dermal fibroblasts, as well as extensive communication of keratinocytes with various other skin cell types as revealed through ligand-receptor pairs. Interactions, such as COL17A1-A1b1complex, highlighted a direct link between keratinocytes and fibroblast stimulation for collagen production. Most importantly, A key gene, MYO1, associated with skin aging was identified, leading to the development of an innovative mRNA treatment aimed at promoting skin rejuvenation by targeting this gene. Experimental results demonstrated that the mRNA treatment reduces basal stem cell senescence, increases basal stem cell proliferation, and enhances collagen production in fibroblasts via keratinocyte-fibroblast communication. The MYO1-targeted treatment is validated as an effective strategy for reversing skin aging by targeting cellular mechanisms.

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Unbiased Proteomic Approach Reveals Rejuvenation-Associated Effects of Quinoa Bioester on Skin

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