C3aR1 on Beta Cells Enhances Beta Cell Function and Surivival to Maintain Glucose Homeostasis
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Pancreatic Islet
SUBMITTER: 
Charles Warren
LAB HEAD: Jacob Geri
PROVIDER: PXD062327 | Pride | 2025-05-07
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| DIANN_processed_data.zip | Other | |||
| FASTA_Mus_Musculus_12-5-2022.fasta | Fasta | |||
| Lo_CW_01282025_Set2_01to5_11to15.d.zip | Other | |||
| report-lib.predicted.speclib | Other |
Items per page: 5 1 - 4 of 4 |
Publications
C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasis.
Pereira de Lima Renan R Li Ang A Gilani Ankit A Rubio-Navarro Alfonso A Warren Charles D CD Kong Isabella Y IY Geri Jacob B JB Lo James C JC
Molecular metabolism 20250404
<h4>Objective</h4>Pancreatic β cell dysfunction is critical to the development of type 2 diabetes (T2D). Our previous studies suggested that C3aR1 on β cells promotes insulin secretion and cell survival. However, as C3aR1 is expressed on many other cell types including within the islets, whole-body C3aR1 knockout models confound the analyses of direct impacts on β cells.<h4>Methods</h4>To clarify the role of C3aR1 in β cells under T2D conditions, we generated β cell-specific C3aR1 knockout mice. ...[more]
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