Ophiobolin A selectively alters mitochondria, metabolism and redox biology in cells which have undergone epithelial to mesenchymal transition
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Yongfeng Tao
LAB HEAD: Ben Cravatt
PROVIDER: PXD062356 | Pride | 2026-02-16
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| B2_67_AE_MB231_OpA_10plex.txt | Txt | |||
| B2_67_AE_MB231_OpA_10plex_01.raw | Raw | |||
| B2_67_AE_MB231_OpA_10plex_02.raw | Raw | |||
| B2_67_AE_MB231_OpA_10plex_03.raw | Raw | |||
| B2_67_AE_MB231_OpA_10plex_04.raw | Raw |
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Publications
Ophiobolin A impacts mitochondrial redox biology in an epithelial-mesenchymal transition (EMT)-specific manner.
Parker Haleigh N HN Tao Yongfeng Y Tobin Jenna J Haberman Kayla L KL Davis Samantha S York Emily E Martinez Alysia A Matsumoto Nobuyuki N Aroujo Jaquelin J Park Jun Hyoung JH Zechmann Bernd B Kaipparettu Benny Abraham BA Boari Angela A Sayes Christie M CM Evidente Antonio A Kornienko Alexander A Cravatt Benjamin B Romo Daniel D Taube Joseph H JH
Cancer cell international 20260114 1
Breast cancer progression is facilitated by the epithelial to mesenchymal transition (EMT), generating cancer cells with enhanced metastatic capacity and resistance to chemotherapeutics. The fungus-derived sesterterpenoid natural produce compound, ophiobolin A (OpA), possesses nanomolar cytotoxic activity and a high therapeutic index, although its molecular targets and mechanism of action are not well characterized. Herein, we utilized a model of mammary epithelial cells and breast cancer cell l ...[more]
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