Proteomics

Dataset Information

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Proteomics of serum extracellular vesicles from patients with advanced melanoma treated with anti-PD1 inhibitors

ABSTRACT: Protein content of extracellular vesicles from serun of advanced melanoma patients treated with anti-PD1 therapy.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Skin Cancer

SUBMITTER: Lucia Trilla-Fuertes  

LAB HEAD: Enrique Espinosa

PROVIDER: PXD062378 | Pride | 2026-02-23

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20241122_C36889_002_S833274_VEM04_2_Group_2.raw Raw
20241122_C36889_003_S833266_VEM01_3_Group_3.raw Raw
20241122_C36889_004_S833278_VEM07_1_Group_1.raw Raw
20241122_C36889_005_S833267_VEM02_1_Group_1.raw Raw
20241122_C36889_007_S833272_VEM03_3_Group_3.raw Raw
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Publications

This study investigates the role of extracellular vesicles (EVs) in predicting melanoma patients' responses to anti-PD1 immunotherapy. Nine patients with advanced melanoma provided blood samples at three stages: before treatment, before the second dose, and either at disease progression or nine months later. EVs were isolated from serum and analyzed using mass-spectrometry proteomics, followed by network and enrichment analyses. Six out of nine patients progressed despite treatment. Before thera  ...[more]

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