Dataset Information

Human Femoral Artery Proteome and 2-Hydroxyisobutyrylation Analysis in Metabolic Syndrome Induced Restenosis

ABSTRACT: Restenosis is the primary complication following stenting for coronary and peripheral arterial disease (PAD), posing an ongoing clinical challenge. Metabolic syndrome (MetS), characterized by metabolic disturbances, has been identified as an independent predictor for postoperative restenosis in coronary and carotid arteries, potentially due to endothelial dysfunction and augmented oxidative stress in cells, while its specific regulatory mechanism is still largely unknown. Lysine 2-hydroxyisobutyrylation (Khib), a recently identified post-translational modification, plays a crucial role in transcriptional regulation and cellular metabolism. However, there is a lack of comprehensive analysis of the proteome and Khib modifications within restenotic vessels in the context of MetS, as well as in the understanding of the associated pathophysiology. Here, we firstly validate changes in expression and distribution of Khib in vascular tissues in clinical tissue and cell models. Subsequently, we utilized proteomics and modifiomics to examine the protein and Khib modification characteristics in MetS-induced restenosis.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Artery

SUBMITTER: Yongxin Li

LAB HEAD: Yongxin Li

PROVIDER: PXD062384 | Pride | 2025-06-23

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	XA01163LP2o.zip	Other
	XA01163LP2o_DISEASE1_Slot1-27_1_8660.d.zip	Other
	XA01163LP2o_DISEASE2_Slot1-28_1_8662.d.zip	Other
	XA01163LP2o_DISEASE3_Slot1-29_1_8664.d.zip	Other
	XA01163LP2o_D_MIX_Slot1-30_1_8666.d.zip	Other

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Publications

Proteomic Analysis and 2-Hydroxyisobutyrylation Profiling in Metabolic Syndrome Induced Restenosis.

Liu Xiangyu X Zhou Liping L Huang Wenjing W Yang Yanyan Y Yang Yijun Y Liu Tianwei T Guo Mingjin M Yu Tao T Li Yongxin Y

Molecular & cellular proteomics : MCP 20250424 6

Restenosis is the primary complication following stenting for coronary and peripheral arterial disease, posing an ongoing clinical challenge. Metabolic syndrome (MetS), characterized by metabolic disturbances, has been identified as an independent predictor for postoperative restenosis in coronary and carotid arteries, potentially due to endothelial dysfunction and augmented oxidative stress in cells, while its specific regulatory mechanism is still largely unknown. Lysine 2-hydroxyisobutyrylati ...[more]

PMID: 40287094

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