Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cerebrospinal Fluid
SUBMITTER: Johan Gobom
LAB HEAD: Johan Gobom
PROVIDER: PXD062585 | Pride | 2025-05-26
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 361 |
Weiner Sophia S Sauer Mathias M Montoliu-Gaya Laia L Benedet Andrea L AL Ashton Nicholas J NJ Gonzalez-Ortiz Fernando F Simrén Joel J Rahmouni Nesrine N Tissot Cecile C Therriault Joseph J Servaes Stijn S Stevenson Jenna J Leinonen Ville V Rauramaa Tuomas T Hiltunen Mikko M Rosa-Neto Pedro P Blennow Kaj K Zetterberg Henrik H Gobom Johan J
Molecular neurodegeneration 20250506 1
<h4>Background</h4>While the temporal profile of amyloid (Aβ) and tau cerebrospinal fluid (CSF) biomarkers along the Alzheimer's disease (AD) continuum is well-studied, chronological changes of CSF proteins reflecting other disease-relevant processes, denoted 'X' in the ATX(N) framework, remain poorly understood.<h4>Methods</h4>Using an untargeted mass spectrometric approach termed tandem mass tag (TMT), we quantified over 1500 CSF proteins across the AD continuum in three independent cohorts, f ...[more]