Proteomics

Dataset Information

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Proteomic analysis of CSF samples from patients across the Alsheimer's disease continuum


ABSTRACT: Proteomic analysis of CSF from patients in different stages of developinf Alzheimer's disease, and healthy control individuals (n=229).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: Johan Gobom  

LAB HEAD: Johan Gobom

PROVIDER: PXD062585 | Pride | 2025-05-26

REPOSITORIES: Pride

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Publications


<h4>Background</h4>While the temporal profile of amyloid (Aβ) and tau cerebrospinal fluid (CSF) biomarkers along the Alzheimer's disease (AD) continuum is well-studied, chronological changes of CSF proteins reflecting other disease-relevant processes, denoted 'X' in the ATX(N) framework, remain poorly understood.<h4>Methods</h4>Using an untargeted mass spectrometric approach termed tandem mass tag (TMT), we quantified over 1500 CSF proteins across the AD continuum in three independent cohorts, f  ...[more]

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