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Global analysis of cancer cell responses to USP9X inhibition

ABSTRACT: HDX-MS experiment using selective USP9X inhibitors WEHI-092, FT709 with recombinant catalytic domain USP9X.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Philipp Schenk

LAB HEAD: David Komander

PROVIDER: PXD062754 | Pride | 2026-04-09

REPOSITORIES: Pride

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			Action	DRS
	230613_Philipp.7z	Other
	230718_PS_cleanup.DnX	Other
	250107_Cluster_Data.csv	Csv
	Search_Results_CSV.7z	Other
	checksum.txt	Txt

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Publications

Global analysis of cancer cell responses to USP9X inhibition.

Schenk Philipp P Devine Shane M SM Cobbold Simon A SA Geoghegan Niall D ND Kyran Elizabeth L EL Ang Ching-Seng CS Alexandrovics Jack A JA Calleja Dale J DJ Multari Dylan H DH Vaibhav Vineet V Lu Bernadine G C BGC Klemm Theresa A TA Dagley Laura F LF Lowes Kym N KN Williamson Nicholas A NA Eichhorn Pieter J A PJA Ng Ashley P AP Feltham Rebecca R Komander David D

The EMBO journal 20260407 9

The ubiquitin-specific protease (USP) USP9X is a human deubiquitinase (DUB) with a large number of described targets and cellular roles. In cancer, USP9X is found as an oncogene or as a tumour suppressor depending on context, and its utility as a target for cancer therapy remains unclear. We here describe WEHI-092, a piperazine-based USP9X-specific small-molecule inhibitor, which binds to a unique region in the USP9X Fingers-subdomain, distinct from known DUB-inhibitor binding sites. Using prote ...[more]

PMID: 41946992

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