Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4

ABSTRACT: In this study, we elucidated the mode of action of a class of drugs as NEDD4 inhibitors. These first-in-class NEDD4 inhibitors demonstrated exceptional specificity and selectivity, leaving the other family members unaffected.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Lung Cancer

SUBMITTER: Elena Maspero  

LAB HEAD: Simona Polo

PROVIDER: PXD062777 | Pride | 2025-05-29

REPOSITORIES: Pride