Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Bos Taurus (bovine)
SUBMITTER:
Klaus Kratochwill
LAB HEAD: Dr Klaus Kratochwill
PROVIDER: PXD062778 | Pride | 2025-11-17
REPOSITORIES: Pride
Items per page: 1 - 5 of 38 |

npj metabolic health and disease 20251107 1
The aquaporin-7 (AQP7) channel mediates glycerol release from adipocytes. Genetic variants decreasing AQP7 expression are associated with adiposity and metabolic complications in humans. Using human data, mouse models, and cellular systems, we investigated how AQP7 influences adipose tissue maturation and homeostasis. Negative correlations between methylation on the AQP7 locus, expression of AQP7 in the adipose tissue and BMI were observed in humans. Mice lacking Aqp7 had increased body weight a ...[more]