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ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells

ABSTRACT: We compare the proteome of the brain endothelial cells obtained with the newly optimized protocol (iCE-BECs) to the primary human brain microvascular endothelial cells (HBMVECs) and the widely used immortalized brain endothelial cell line HCMECD3. The goal is to investigate the applicability of iCE-BECs for transport assays, measuring the expression of transporters and receptors with whole cell proteomics.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Christine Becker

LAB HEAD: Martina Pigoni

PROVIDER: PXD062808 | Pride | 2025-08-08

REPOSITORIES: Pride

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			Action	DRS
	20230913_PS16366_BBB_Proteome_profiling_of_endothelial_cells_in_vitro_models_Report_for_Stats.xls	Xls
	230907_PS16366_BBB_10_iBEC_GV23_010.raw	Raw
	230907_PS16366_BBB_11_iBEC_MP23_031_iBEC_differentiation_290623.raw	Raw
	230907_PS16366_BBB_12_iBEC_MP23_032_iBEC_differentiation_060723.raw	Raw
	230907_PS16366_BBB_13_iBEC_MP23_033_iBEC_differentiation_130723.raw	Raw

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