Dataset Information

Early proteomic response in thyroid gland after I-131 administration in female Balb/c mice

ABSTRACT: 131I (iodide) accumulates in the thyroid and may affect thyroid tissue. Mechanisms behind such effects are not known. The aim was to investigate early changes in protein expression in thyroid and plasma from mice injected with 131I as iodide. Female Balb/c nude mice were i.v. injected with 0 or 490 kBq 131I, and killed after 24 h. Thyroid and blood samples were collected from each animal. Protein levels were determined by mass spectrometry. Altogether, 17 and 20 proteins showed statistically significant altered levels in thyroid gland and plasma, respectively, after 131I exposure. Most of these proteins had decreased and increased levels in thyroid and plasma, respectively. Few of them were previously proposed radiation responsive proteins. Functional annotation suggests impact on haematopoiesis, reduced oxygen levels, and hypothyroidism. The role of CHIA and PGAM2 in radiation-induced response should be further examined, together with identification and validation of biomarkers of 131I exposure.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma, Thyroid Gland

DISEASE(S): Hyperthyroidism

SUBMITTER: Johannes Fuchs

LAB HEAD: Johan Spetz

PROVIDER: PXD062861 | Pride | 2025-09-08

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	1926_set1_Swissprot_mouse_TMT10plex_Fusion_140925_07_18.msf	Msf
	1926_set2_Swissprot_mouse_TMT10plex_Fusion_140925_21_32_ver2.msf	Msf
	Fusion_140925_07.raw	Raw
	Fusion_140925_08.raw	Raw
	Fusion_140925_09.raw	Raw

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Early proteomic response in thyroid gland after 131I administration in female Balb/c mice.

Rudqvist Nils N Spetz Johan J Schüler Emil E Parris Toshima Z TZ Langen Britta B Wallem Carina Sihlbom CS Helou Khalil K Forssell-Aronsson Eva E

Radiation protection dosimetry 20250801 13-14

131I (iodide) accumulates in the thyroid and may affect thyroid tissue. Mechanisms behind such effects are not known. The aim was to investigate early changes in protein expression in thyroid and plasma from mice injected with 131I as iodide. Female Balb/c nude mice were i.v. injected with 0 or 490 kBq 131I and killed after 24 h. Thyroid and blood samples were collected from each animal. Protein levels were determined by mass spectrometry. Data are available via ProteomeXchange with identifier P ...[more]

PMID: 40875264

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