Proteomics

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Proteomics analysis of involvemnt of miRNA 465 in hybrid mouse sterility, 12 days

ABSTRACT: One of the reproductive isolation mechanisms that restricts gene exchange and make speciation irreversible is sterility of inter(sub)specific hybrids. In the Prdm9-driven sterility of Mus m. musculus x Mus m. domesticus hybrids a Prdm9-interacting hybrid sterility gene was mapped in the X-linked Hstx2 locus. Here we show that the Mir465 microRNA gene cluster is the predicted Hstx2 hybrid sterility factor involved in Prdm9 interaction.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Male Germ Cell

DISEASE(S): Disease Free

SUBMITTER: Lucie Pfeiferova  

LAB HEAD: Jiri Forejt

PROVIDER: PXD062935 | Pride | 2026-04-06

REPOSITORIES: Pride

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PLK230_OE480_240429_IMG21_1994WT_2-7uL_DIA-FAIMS_120M_90G.raw Raw
PLK230_OE480_240429_IMG21_1995KO_2-9uL_DIA-FAIMS_120M_90G.raw Raw
PLK230_OE480_240429_IMG21_1996WT_2-4uL_DIA-FAIMS_120M_90G.raw Raw
PLK230_OE480_240429_IMG21_1999KO_2-8uL_DIA-FAIMS_120M_90G.raw Raw
PLK230_OE480_240429_IMG21_4371WT_2-7uL_DIA-FAIMS_120M_90G.raw Raw
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Publications

Mouse X-linked microRNA cluster regulates the meiotic checkpoint and <i>Prdm9</i>-driven hybrid sterility in a copy number-dependent manner.

Jansa Petr P   Tanieli Giordano G   Vucinic Kim K   Lustyk Diana D   Fusek Karel K   Valiskova Barbora B   Morimoto Kento K   Mizuno Seiya S   Ullrich Kristian K   Odenthal-Hesse Linda L   Provaznik Jan J   Benes Vladimir V   Pfeiferova Lucie L   Kolar Michal M   Gergelits Václav V   Pialek Jaroslav J   Forejt Jiri J  

Proceedings of the National Academy of Sciences of the United States of America 20251002 40

One of the reproductive barriers between diverging populations during formation of a new species is the sterility of their hybrids. The <i>Prdm9-</i>driven hybrid male sterility of <i>Mus musculus musculus</i> × <i>Mus musculus domesticus</i> hybrids depends on the interaction between PRDM9, a histone methyltransferase that determines the positions of meiotic recombination hotspots, and an as yet unknown X-linked genetic factor within the Hybrid sterility X2 (<i>Hstx2</i>) locus. Here, we report  ...[more]

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