Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders

ABSTRACT: We characterized the sperm proteins recognized by the antibodies in mouse serum and epididymal fluid after immune tolerance disruption by performing mass spectrometry-based label-free quantitative proteomics. For this, we immunoprecipitated sperm cell protein extractions with serum and epididymal fluids from the proximal and distal epididymis of WT and Foxp3-DTR transgenic mice 2 weeks after Treg depletion.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Sperm

SUBMITTER: Maria Agustina Battistone  

LAB HEAD: Maria Agustina Battistone

PROVIDER: PXD062944 | Pride | 2025-07-10

REPOSITORIES: Pride