Proteomics

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SWATH-MS-based proteome analysis of PBA-enriched glycated/ glycosylated proteins from knee synovial fluid in osteoarthritis (OA) and osteoarthritis with type 2 diabetes mellitus (OADM)

ABSTRACT: Osteoarthritis (OA) severity is often exacerbated in individuals with type 2 diabetes mellitus (T2DM), giving rise to a co-morbid condition (OADM) characterized by enhanced metabolic and degenerative alterations. However, the molecular mechanisms underlying this association remain insufficiently understood. In this study, we performed a SWATH-MS-based global proteomic analysis of phenylboronic acid (PBA)-enriched cis-diol–containing glycated/ glycosylated proteins from knee synovial fluid samples of OA and OADM patients. The dataset captures differentially abundant protein signatures associated with metabolic dysregulation, extracellular matrix remodeling, and inflammatory processes in OADM. From a translational perspective, these proteins may have potential relevance as candidate biomarkers for distinguishing OADM from OA and for supporting future investigations into disease stratification and targeted therapeutic approaches.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Type 2 Diabetes Mellitus,Osteoarthritis

SUBMITTER: Ayushi Sharma  

LAB HEAD: Jyotdeep Kaur

PROVIDER: PXD062955 | Pride | 2026-03-27

REPOSITORIES: Pride

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PBA-enriched glycated/ glycosylated synovial fluid proteomic signatures associated with metabolic dysregulation and cartilage degeneration in osteoarthritis with type 2 diabetes.

Sharma Ayushi A   Saini Uttam Chand UC   Bhadada Sanjay Kumar SK   Sharma Sadhna S   Kaur Jyotdeep J  

Journal of translational medicine 20260325 1

BACKGROUND: Osteoarthritis (OA) frequently co-exists with type 2 diabetes mellitus (T2DM) owing to shared risk factors, including age and obesity, and disease severity is often greater in individuals with both conditions (OADM). However, molecular alterations associated with this co-morbidity remain incompletely understood. Here, we applied a proteomics-based approach to investigate glycated/ glycosylated synovial fluid (SF) proteins and to identify molecular patterns potentially linked to joint  ...[more]

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