Proteomics

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Osteogenic differentiation regulation of canine periodontal ligament stem cells by hydrogel containing magnetic nanoparticles

ABSTRACT: Bone defect architecture has become an issue to resemble in scaffold properties, beside enhancing osteoinduction. Thus, a non-invasive injectable approach is proposed by using silk fibroin (SF)-based hydrogel containing magnetic nanohydroxyapatite (MHAp) and osteogenic growth peptide (OGP). This study aimed to disseminate the osteogenic differentiation potential of the hydrogel and its mechanism on canine periodontal ligament stem cells (cPDLSCs). The addition of MHAp and/or OGP into the hydrogel shows remarkable osteogenic differentiation by the elevated ALP activity, osteogenic marker expression, and biomineralization. Proteomics analysis results revealed that TGF-β, BMP, and Notch signaling pathways are involved in the injectable hydrogel-induced osteogenic differentiation of cPDLSCs, validated by inhibition assay. Overall, HG/OGP/MHAp shows potential to be used in clinical practice for treating alveolar bone defects.

INSTRUMENT(S):

ORGANISM(S): Canis Lupus Lupus

TISSUE(S): Stem Cell

DISEASE(S): Disease Free

SUBMITTER: Poorichaya Somparn  

LAB HEAD: Poorichaya Somparn

PROVIDER: PXD063171 | Pride | 2026-05-25

REPOSITORIES: Pride

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The architecture of bone defects presents a challenge in designing scaffolds that support structural integrity and enhance osteoinduction. To address this, a noninvasive injectable silk fibroin (SF)-based hydrogel incorporating magnetic nanohydroxyapatite (MHAp) and osteogenic growth peptide (OGP) was developed. This study investigated the osteogenic differentiation potential of the hydrogel and its underlying mechanism on canine periodontal ligament stem cells (cPDLSCs). The incorporation of MH  ...[more]

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