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Stress-induced NONO interactomes

ABSTRACT: Characterization of sulforaphane- and starvation-induced NONO interactomes in wild type andNEAT1 knockout MCF7 cells

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Maria Perander

LAB HEAD: Maria Perander

PROVIDER: PXD063223 | Pride | 2026-01-16

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	220525_E_IOdonkor_TMTgr1.raw	Raw
	220525_E_IOdonkor_TMTgr2.raw	Raw
	220525_E_IOdonkor_TMTgr3.raw	Raw
	220525_E_IOdonkor_TMTgr4.raw	Raw
	NonoTMTproteinGroups.txt	Txt

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1 - 5 of 5

Publications

Stress-specific NONO interactomes reveal a key role of Hsp70 chaperone activity in regulation of paraspeckle formation.

Odonkor Isaac I Shrestha Birendra Kumar BK Nielsen Stephanie Rose SR Kournoutis Athanasios A Bjørlo Ida Emilie IE Das Sajib Saikat S Hedberg Annica A Grønset Toril Anne TA Larsen Kenneth Bowitz KB Bruun Jack-Ansgar JA Knutsen Erik E Lellahi Seyed Mohammad SM Perander Maria M

Journal of cell science 20260123 2

Paraspeckles are stress-induced nuclear RNA-protein condensates that assemble on the long non-coding RNA NEAT1. Their increased formation under certain cellular circumstances has gained growing interest due to their association with serious human diseases, such as neurodegenerative disorders and cancer. The biological functions of paraspeckles still appear obscure, but increasing evidence suggests that they contribute to regulation of gene expression by recruiting specific proteins and RNA molec ...[more]

PMID: 41416371

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Transcriptome changes in MCF7 cells after treatment with NONO ligands and controls

Project description:RNA-Sequencing to determine transcriptome changes in MCF7 cells after treatment with NONO ligands and controls. NONO knockout (sgNONO) or control (sgControl) cells were treated.

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Transcriptome changes in 22Rv1 and MCF7 cells after treatment with NONO ligands and controls

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Transcriptional profile of human breast cancer MCF7 cells and clones thereof expressing human ERβ1 or ERβ2 upon treatment with antiestrogens and retinoids.

Project description:The aim of the experiment was to gain insight into the role of estrogen receptor beta (ERβ) isoforms in the response of breast cancer MCF7 cells to antiestrogens and retinoids. To this end, clones of MCF7 cells constitutively expressing human ERβ1 (MCF7-ERβ1) or ERβ2 (MCF7-ERβ2) were established and used for the determination of the global transcriptional changes induced upon treatment with hydroxytamoxifen (OHT) and all-trans retinoic acid (ATRA). Gene signatures associated with each clone will shed light to the mechanism underlying the ERβ1- and ERβ2-mediated response of MCF7 cells to antiestrogens and retinoids.

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Effect of HIC1 and miR-212/132 expression on MCF7 cells

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