Dataset Information

PirB-CTF LC-MS/MS in hippocampus

ABSTRACT: Our result indicated PirB could undergo proteolytic process, generating a C-terminal fragment (PirB-CTF). We found PirB-CTF can translocates to the Golgi apparatus, disrupting Golgi-dependent protein transport. To investigate the novel binding partners which mediated the effect of PirB-CTF, we used mass spectrometry analysis.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Cns Neuron (sensu Nematoda And Protostomia)

DISEASE(S): Disease Free

SUBMITTER: wubo Han

LAB HEAD: Suya Sun

PROVIDER: PXD063306 | Pride | 2026-06-08

REPOSITORIES: Pride

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Publications

Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration.

Han Wu-Bo WB Liu Xian-Dong XD Tang Chang-Fei CF Zheng Junke J Xu Tian-Le TL Xu Nan-Jie NJ Sun Suya S

Translational neurodegeneration 20260603 1

<h4>Background</h4>Extensive research evidence indicates that neuronal immune receptors play a critical role in Alzheimer's disease (AD). However, it remains unclear how these receptors convert extracellular signals into cellular pathological changes. Proteolytic cleavage of membrane receptors serves as an unconventional pathway for reprogramming cellular functions, and the cleaved fragments often play important roles within the cell. Whether immune receptors mediate their effects in AD through ...[more]

PMID: 42231420

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			Action	DRS
	Analysis.zip	Other
	XNJ_CTF_1.raw	Raw
	XNJ_CTF_2.raw	Raw
	XNJ_CTF_3.raw	Raw
	XNJ_GFP_1.raw	Raw