Proteomics

Dataset Information

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Tirzepatide reduces alcohol drinking, modulates reward processing, and alters lateral septum proteome in preclinical models of AUD

ABSTRACT: This study explored the therapeutic potential of tirzepatide, a dual glucagon-like peptide-1 receptor (GLP-1R)/glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist, in preclinical models of AUD, while elucidating the neurobiological mechanisms mediating its effects. Our methodological approach involved reward-related behaviors, alcohol consumption paradigms, and molecular techniques including neurochemical, neurophysiological, and proteome analysis in rodents. Tirzepatide administration attenuated alcohol-induced locomotor stimulation, conditioned place preference, and accumbal dopamine release. Global proteomic analysis revealed altered histone and chromatin regulatory proteins in the lateral septum of tirzepatide-treated alcohol-consuming rats.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

DISEASE(S): Alcohol Dependence

SUBMITTER: Johannes Fuchs  

LAB HEAD: Elisabet Jerlhag

PROVIDER: PXD063324 | Pride | 2026-01-23

REPOSITORIES: Pride

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Dataset's files

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Action DRS
5095_SPrat_TMT_Eclipse_241128_FAIMS_05to40.msf Msf
5095_SPrat_TMT_Eclipse_241128_FAIMS_05to40.pdResult Other
5095_StudyDesignResults.xlsx Xlsx
Eclipse_241128_FAIMS_05.raw Raw
Eclipse_241128_FAIMS_06.raw Raw
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Publications

<h4>Background</h4>Alcohol use disorder (AUD) remains a major public health problem, with few effective medications currently available. However, peptides of the gut-brain axis appear to offer promising therapeutic targets for AUD as they influence the mesolimbic reward circuitry.<h4>Methods</h4>Here, we examined the effects of tirzepatide, a long-acting dual glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist approved for diabetes a  ...[more]

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