Mass spectrometry analysis of the cytoplasmic histones within CD4+ T cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, T Cell
SUBMITTER: 
博涵 徐
LAB HEAD: Li Liang
PROVIDER: PXD063335 | Pride | 2025-06-16
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| He24YCX_H2B_T3-positive_6_S1-F2_1_5524.d.zip | Other | |||
| checksum.txt | Txt | |||
| proteins_anno_detail.xls | Xls |
Items per page: 5 1 - 3 of 3 |
Publications
Cytoplasmic Histone Is a Marker of Pro-Inflammatory CD4 <sup>+</sup> T Cells.
Xu Bohan B Liu Guanglong G Peng Yifang Y Chen Chuxi C Li Bingsong B Zhu Tianning T Huang Nan N Zhong Jianyun J Zhang Kang K Wang Zhizhang Z
Immunology 20250604 1
Although extranuclear histones have been identified for a long time, their role in lymphocytes, particularly cytoplasmic histones, remains elusive. In this study, we conducted a visual and quantitative analysis of cytoplasmic histones in CD4<sup>+</sup> T cells and discovered that effector CD4<sup>+</sup> T cells contain higher levels of cytoplasmic histones compared to naïve T cells. We observed a significant increase in cytoplasmic histones following T cell receptor (TCR) activation, with furt ...[more]
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