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Spatial distribution of the proteome in the human body and in cancers

ABSTRACT: A detailed, spatially resolved quantitative map of the human proteome is essential for a deeper understanding of human biology anddisease. Here we present a comprehensive human proteomic landscape, generated by profiling more than 13,000 proteinsacross 2,856 samples using data-independent acquisition mass spectrometry. The dataset spans 58 major tissue types, 251 specifictissue subtypes and 25 distinct carcinomas. This resource enables the depiction of spatially resolved proteome trajectories across tissuetypes and physiological states, including fetal, tumour, adjacent non-tumour and healthy adult tissue, thereby providing insight intoboth developmental processes and oncogenic progression. Furthermore, quantitative proteomics comparisons across diverse tissue typesand states facilitate the prediction of organ-specific toxicity, the identification of repurposable anticancer drug candidates and theprioritization of therapeutic targets for cancers. This study establishes a quantitative resource for navigating the proteome in the humanbody and in common cancers.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Whole Body

SUBMITTER: Tiannan Guo

LAB HEAD: Tiannan Guo

PROVIDER: PXD063370 | Pride | 2026-05-28

REPOSITORIES: Pride

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			Action	DRS
	20230313TPHP_PRM_prot_matrix_48.csv	Csv
	B20211019yuel_TPHP_PRM_30min_CA002.raw	Raw
	B20211019yuel_TPHP_PRM_30min_CA003.raw	Raw
	B20211019yuel_TPHP_PRM_30min_CA004.raw	Raw
	B20211019yuel_TPHP_PRM_30min_CA005.raw	Raw

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