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AfBPP of N-substituted oligobenzamide α-helix mimetics

ABSTRACT: A wide range of small molecule scaffolds capable of mimicking protein α-helices to modulate protein-protein interactions have been reported, yet their target selectivity is poorly understood. Here, we report the affinity-based protein profiling of three structurally distinct classes of α-helix mimetics, N-substituted oligobenzamides, pyrrolopyrimidines, and oxopiperazines, all reported to inhibit the interaction between the tumour suppressor protein p53 and its negative regulator murine double minute 2 (MDM2).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Amrita Date

LAB HEAD: Anna Barnard

PROVIDER: PXD063390 | Pride | 2026-08-05

REPOSITORIES: Pride

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			Action	DRS
	AD_MS_046_OB-b3_A_S3-D2_1_6104.d.zip	Other
	AD_MS_046_OB-b3_B_S3-D5_1_6107.d.zip	Other
	AD_MS_046_OB-b3_C_S3-D8_1_6111.d.zip	Other
	AD_MS_046_OB-b3_D_S3-D11_1_6114.d.zip	Other
	AD_MS_046_OB-b3_OB-b_A_S3-D3_1_6105.d.zip	Other

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