AfBPP of pyrrolopyrimidine α-helix mimetics

ABSTRACT: A wide range of small molecule scaffolds capable of mimicking protein α-helices to modulate protein-protein interactions have been reported, yet their target selectivity is poorly understood. Here, we report the affinity-based protein profiling of three structurally distinct classes of α-helix mimetics, N-substituted oligobenzamides, pyrrolopyrimidines, and oxopiperazines, all reported to inhibit the interaction between the tumour suppressor protein p53 and its negative regulator murine double minute 2 (MDM2).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Amrita Date  

LAB HEAD: Anna Barnard

PROVIDER: PXD063432 | Pride | 2026-08-05

REPOSITORIES: Pride