Effects of hypoxia on brain protein expression in a mouse model of Parkinson's disease

ABSTRACT: The purpose of this study was to evaluate whether chronic, continuous hypoxia (breathing 11% FIO2) would improve neurodegenerative disease in a mouse model of Parkinson's disease, which was modeled through intrastriatal injection of a-synuclein preformed fibrils (PFFs). We find that chronic, continuous hypoxia helps to prevent further neurodegeneration and alleviate neurological disease.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Substantia Nigra

DISEASE(S): Parkinson's Disease

SUBMITTER: Timothy Durham  

LAB HEAD: Vamsi Mootha

PROVIDER: PXD063553 | Pride | 2025-07-14

REPOSITORIES: Pride