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Association of heme bound HRI with S-DELE1 promotes structural re-arrangements within the HRI kinase domain

ABSTRACT: This dataset assesses structural changes occurring in human, heme-bound HRI upon association with S-DELE1. To this end, human HRI and S-DELE1 were expressed EIF2alpha phosphorylation-resistent cells supplemented with hemin. HRI was affinity purified, crosslinked with DSS, and structural changes in HRI were assessed by MS. The data set identifies S-DELE1 induced structural changes in the C-terminal region and the kinase insert of HRI, as well as domains of HRI that are in structural proximity to S-DELE1.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Barbara Steigenberger

LAB HEAD: Lucas Jae

PROVIDER: PXD063587 | Pride | 2026-05-07

REPOSITORIES: Pride

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			Action	DRS
	202401217_EXPL6_Neo_BaSt_SA_Orbi5445_sample01.raw	Raw
	202401217_EXPL6_Neo_BaSt_SA_Orbi5445_sample01_Crosslinks.txt	Txt
	202401217_EXPL6_Neo_BaSt_SA_Orbi5445_sample02.raw	Raw
	202401217_EXPL6_Neo_BaSt_SA_Orbi5445_sample02_Crosslinks.txt	Txt
	202401217_EXPL6_Neo_BaSt_SA_Orbi5445_sample03.raw	Raw

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