LC-MS data of IM95 gastric cancer cells following YAP degradation by bioPROTAC

ABSTRACT: In this study, through naïve nanobody phage library screening, we have identified multiple nanobodies against human YAP with high affinity and specificity. The YAP nanobody was then fused to the RING domain of RNF4, creating a bio-Proteolysis-Targeting Chimera (bioPROTAC) molecule capable of selectively targeting endogenous YAP for ubiquitin-mediated degradation.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Regulation Of Gastric Acid Secretion, Cell Culture

DISEASE(S): Diffuse Gastric Cancer

SUBMITTER: Gui-Ming Zhang  

LAB HEAD: Gui-Ming Zhang

PROVIDER: PXD063726 | Pride | 2025-11-03

REPOSITORIES: Pride