Structural analysis of the CSN complex to understand its inhibition mechanism

ABSTRACT: We performed interaction and structural analyses to unravel the molecular mechanisms underlying CSN inhibition. Various methods including Cryo-EM, cross-linking mass spectrometry, quantitative mass spectrometry and biochemical assays have been employed to define inhibitor-induced interaction and structural changes of the CSN complex in vitro and in cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Embryonic Stem Cell

SUBMITTER: Fenglong Jiao  

LAB HEAD: Lan Huang

PROVIDER: PXD063786 | Pride | 2025-11-20

REPOSITORIES: Pride