Dataset Information

The covalent bonding of beta-2-microglobulin with HLA class I influences the antigenic landscape of cells

ABSTRACT: Here, we investigate the effect that a constant interaction of beta-2m with HLA-I molecules can have on what antigens and peptides are displayed upon direct- and cross-presentation. When beta-2m is linked to HLA-I molecules the antigenic landscape is modified compared to physiological conditions.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Blood

DISEASE(S): Acute Leukemia,Lymphoma

SUBMITTER: Yehor Horokhovskyi

LAB HEAD: Henning Urlaub

PROVIDER: PXD063813 | Pride | 2026-06-04

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	MR_SP_J_Liepe_121124_300125_TIMS_set2_C1R-A02-NoB2M_inj1_bio1_DIAHiSe_50min_GB2_1_4894.d.zip	Other
	MR_SP_J_Liepe_121124_300125_TIMS_set2_C1R-A02-NoB2M_inj1_bio2_DIAHiSe_50min_GB3_1_4895.d.zip	Other
	MR_SP_J_Liepe_121124_300125_TIMS_set2_C1R-A02-NoB2M_inj1_bio3_DIAHiSe_50min_GB4_1_4896.d.zip	Other
	MR_SP_J_Liepe_121124_300125_TIMS_set2_C1R-A02-NoB2M_inj2_bio1_DIAHiSe_50min_GB2_1_4914.d.zip	Other
	MR_SP_J_Liepe_121124_300125_TIMS_set2_C1R-A02-NoB2M_inj2_bio2_DIAHiSe_50min_GB3_1_4915.d.zip	Other

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Publications

Stable β2-Microglobulin-HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer-Associated Epitopes.

Barajas Molina Ana A Horokhovskyi Yehor Y Acuti Nicole N Chong Yee Kien YK Phanichkrivalkosil Meghna M Siddons Sophie S Afrache Hassnae H Maloney Megan M Soh Wai Tuck WT Hofland Tom T Hall Callum C Urlaub Henning H Kassiotis George G Liepe Juliane J Mishto Michele M

European journal of immunology 20260501 5

β2-Microglobulin (β2m) is essential for the stability and surface expression of human leukocyte antigen class I (HLA-I) molecules. While β2m's structural role is well established, its influence on the antigenic landscape remains incompletely understood. Here, we investigated how constitutive β2m binding to HLA-I influences the antigenic landscape in the context of cancer-associated epitopes. Using two engineered cell lines expressing β2m fused to the HLA-I heavy chain, we analysed changes in imm ...[more]

PMID: 42204932

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