The covalent bonding of beta-2-microglobulin with HLA class I influences the antigenic landscape of cells

ABSTRACT: Here, we investigate the effect that a constant interaction of beta-2m with HLA-I molecules can have on what antigens and peptides are displayed upon direct- and cross-presentation. When beta-2m is linked to HLA-I molecules the antigenic landscape is modified compared to physiological conditions.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Blood

DISEASE(S): Acute Leukemia,Lymphoma

SUBMITTER: Yehor Horokhovskyi  

LAB HEAD: Henning Urlaub

PROVIDER: PXD063813 | Pride | 2026-06-04

REPOSITORIES: Pride