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Antibody-drug conjugate stability probed by variable-temperature electrospray ionization mass spectrometry

ABSTRACT: The stability of hinge-deleted and mutated IgG4, as well as lysine- (Trastuzumab emtansine) and cysteine-based ADCs (Enfortumab vedotin, Brentuximab vedotin) was probed with vT-ESI-MS.

INSTRUMENT(S): Thermo Fisher Scientific instrument model

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Dina Schuster

LAB HEAD: Albert J. R. Heck

PROVIDER: PXD063887 | Pride | 2025-05-22

REPOSITORIES: Pride

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			Action	DRS
	20240829_EMR2_Schus004_ADC_Brentuximab_vedotin_1uM.RAW	Raw
	20240829_EMR2_Schus004_ADC_Brentuximab_vedotin_1uM_rampdata.txt	Txt
	20240904_EMR2_Fiala002_IgG4_2F8_HG_WT_2p5uM_20240904152428.RAW	Raw
	20240904_EMR2_Fiala002_IgG4_2F8_HG_WT_2p5uM_20240904152428_rampdata.txt	Txt
	20240904_EMR2_Fiala002_IgG4_2F8_L368A_2p5uM_20240905115849.RAW	Raw

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