Analysis of KL107 and KL102 glycovaccines
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Escherichia Coli
SUBMITTER: 
Nichollas Scott
LAB HEAD: Christian M. Harding
PROVIDER: PXD063900 | Pride | 2026-01-12
REPOSITORIES: Pride
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Publications
A multivalent capsule vaccine protects against Klebsiella pneumoniae bloodstream infections in healthy and immunocompromised mice.
Wantuch Paeton L PL Robinson Lloyd S LS Knoot Cory J CJ Darwech Isra I Matsuguma Aline M AM Vinogradov Evgeny E Scott Nichollas E NE Harding Christian M CM Rosen David A DA
NPJ vaccines 20251213 1
Klebsiella pneumoniae is a leading cause of nosocomial infections, bacteremia, and worldwide mortality. Further, a drastic rise in antibiotic-resistant isolates poses an urgent threat to humanity. Unfortunately, despite its clinical importance, a licensed K. pneumoniae vaccine is not yet available. Here, we report on the production and characterization of the broadest K. pneumoniae capsule bioconjugate vaccine to date. We tested this vaccine for its immunogenicity, functionality, efficacy, and a ...[more]
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