Dataset Information
Pancreatic cancer cell samples (DDA)
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Farnusch Kaschani
LAB HEAD: Farnusch Kaschani
PROVIDER: PXD063913 | Pride | 2026-04-21
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ACE_0882_NK01.raw | Raw | |||
| ACE_0882_NK02.raw | Raw | |||
| ACE_0882_NK03.raw | Raw | |||
| ACE_0882_NK04.raw | Raw | |||
| ACE_0882_NK05.raw | Raw |
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Publications
Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors.
Nature communications 20260513 1
Proteolysis-targeting chimeras (PROTACs) co-op the ubiquitin system for targeted protein degradation, creating opportunities to interrogate cellular functions of proteins through "chemical knockdown". However, matched pairs of protein degraders and inhibitors, that possess high specificity and chemical complementarity, for individual components of the ubiquitin system have remained scarce. This includes reagents to modulate activity and abundance of deubiquitinases (DUBs). Here, using an integra ...[more]
