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Pathological meprin a activity associated with degradation of dermokine drives a psoriasis-like skin phenotype in a novel genetic mouse model

ABSTRACT: Keratinocyte proliferation and differentiation is regulated via proteolytic networks. Dysregulation of proteases within these systems can cause hyperproliferative and inflammatory skin disorders. In healthy skin the metalloprotease meprin α is localized in the stratum basale, yet in wound healing tissue and psoriatic lesions meprin α is synthesized at higher levels and translocalized to upper epidermal layers. We developed a transgenic mouse model for inducible expression of pathological meprin α levels (K5Mα) to investigate its epidermal degradome and, thereby, identify molecular links to keratinocyte proliferation and skin inflammation.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Keratinocyte, Skin

DISEASE(S): Psoriasis

SUBMITTER: Vahap Canbay

LAB HEAD: Sascha Rüffer

PROVIDER: PXD063928 | Pride | 2026-02-03

REPOSITORIES: Pride

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			Action	DRS
	20230525_EV_EVO_KK_FAIMS_2CV_Endurance_15SPD_DDMS2_TMTpro_1711_Kiel_TAILS_1_NPO.raw	Raw
	20230525_EV_EVO_KK_FAIMS_2CV_Endurance_15SPD_DDMS2_TMTpro_1711_Kiel_TAILS_1_PO.raw	Raw
	20230525_EV_EVO_KK_FAIMS_2CV_Endurance_15SPD_DDMS2_TMTpro_1711_Kiel_TAILS_2_NPO.raw	Raw
	20230525_EV_EVO_KK_FAIMS_2CV_Endurance_15SPD_DDMS2_TMTpro_1711_Kiel_TAILS_2_PO.raw	Raw
	20230525_EV_EVO_KK_FAIMS_2CV_Endurance_15SPD_DDMS2_TMTpro_1711_Kiel_TAILS_3_NPO.raw	Raw

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