Dataset Information

The surfaceome of chondrogenic cells

ABSTRACT: Chondrogenesis, the process through which cartilage forms, has implications for cartilage repair and osteoarthritis (OA) management. In this study, we present the first comprehensive quantitative analysis of the surfaceome of chondrogenic cells using a well-established in vitro chondrogenic model. By employing glycocapture-assisted enrichment targeting sialic acid residues on surface proteins, combined with high-throughput shotgun mass spectrometry, we identified novel components of the chondrogenic cell surfaceome.

INSTRUMENT(S):

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Chondrocyte Development, Chondrocyte

DISEASE(S): Osteoarthritis

SUBMITTER: David Boocock

LAB HEAD: David Boocock

PROVIDER: PXD064013 | Pride | 2026-01-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	220721_Lysate_CsabaMatta_Lysates_7600_8uL_TrEMBL_GallusGallus_Lib.tsv	Tabular
	220721_Lysate_CsabaMatta_Lysates_7600_8uL_report.pg_matrix.tsv	Tabular
	220721_Lysate_CsabaMatta_zSWATH_8uL_D10_1.wiff	Wiff
	220721_Lysate_CsabaMatta_zSWATH_8uL_D10_1.wiff.scan	Wiff
	220721_Lysate_CsabaMatta_zSWATH_8uL_D10_1.wiff2	Wiff

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Publications

Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells.

Kovács Patrik P Brazda Peter P Hajdú Tibor T Harsányi Boglárka B Juhász Krisztián K Takács Roland R Vágó Judit J Wang Zhangzheng Z Coveney Clare C Boocock David J DJ Matta Csaba C

Cell communication and signaling : CCS 20251202 1

BACKGROUND: Osteoarthritis is a degenerative joint disease characterized by progressive loss of articular cartilage and limited capacity for intrinsic repair. A major barrier to developing effective regenerative strategies is the incomplete understanding of the molecular mechanisms regulating chondrogenesis and cartilage maintenance. Cell surface proteins are key mediators of extracellular communication, adhesion, and signaling, yet the chondrogenic surfaceome remains incompletely mapped, with p ...[more]

PMID: 41327293

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