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Cortical Organoids Exposed to Human Milk Oligosaccharides

ABSTRACT: We verify the alterations the the proteome profile of organoids exposed to different concentrations of milk oligosaccharides.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Paulo Carvalho

LAB HEAD: Alysson R. Muotri

PROVIDER: PXD064071 | Pride | 2026-03-16

REPOSITORIES: Pride

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			Action	DRS
	20250311_Milk_Bulk_DIA_Sample_1_Rep_1.raw	Raw
	20250311_Milk_Bulk_DIA_Sample_1_Rep_2.raw	Raw
	20250311_Milk_Bulk_DIA_Sample_1_Rep_3.raw	Raw
	20250311_Milk_Bulk_DIA_Sample_2_Rep_1.raw	Raw
	20250311_Milk_Bulk_DIA_Sample_2_Rep_2.raw	Raw

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Publications

Human milk oligosaccharides promote synaptogenesis and neurite outgrowth in human cortical organoids.

Bulcão V C Luisa L Moreira Natalia C S NCS Carvalho Paulo C PC Luz Isabelle S IS de S da G Fischer Juliana J Tsu Blake L BL Sejane Kristija K Savo Celina C Martins Aline M A AMA Bode Lars L Muotri Alysson R AR

Biochemistry and biophysics reports 20260228

The first 1000 days of a child's life represent a critical window for brain development, during which nutrition exerts profound effects on the trajectories of neurodevelopment. Human Milk Oligosaccharides (HMOs), a major component of human milk, are largely indigestible by infants and are known to influence immunity, microbiome composition, and gut-brain signaling, but their direct role in neurodevelopment remains poorly understood. Here, we investigated the impact of HMOs on human cortical orga ...[more]

PMID: 41799697

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