Proteomic and transcriptomic profiling identifies TIPRL as a potential target in multiple myeloma with 1q gain

ABSTRACT: Amplification or gain of chromosome 1q (+1q) is a common genomic alteration occurring in nearly 40% of multiple myeloma patients. Although it is associated with poor prognosis and advanced disease stages, the impact of +1q at the proteomic level remains unclear. Here, we studied sorted CD138+ plasma cells from the bone marrow from newly diagnosed multiple myeloma to uncover molecular alterations associated with +1q. Differential expression analysis revealed significantly increased expression of several proteins encoded by 1q region indicating potential gene dosage effect. Protein pathway enrichment analysis identified enrichment of cell cycle pathway among proteins with increased expression in +1q. Further, protein-protein interaction network analysis showed enrichment of MYC transcriptional targets including increased expression of TIPRL (located on 1q23) in +1q cases. In agreement with these findings, increased TIPRL transcript expression was correlated with +1q across different primary driver genomic alterations in MM in the CoMMPass dataset. High TIPRL protein expression was further associated with poor prognosis in cases with hyperdiploidy. Overall, this study highlights the role of proteomics in understanding molecular events associated with chromosomal alterations in multiple myeloma and identifying potential targets for further functional analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

DISEASE(S): Multiple Myeloma

SUBMITTER: Akhilesh Pandey  

LAB HEAD: AKhilesh Pandey

PROVIDER: PXD064132 | Pride | 2026-05-13

REPOSITORIES: Pride