Dataset Information

Proteomics and phosphoproteomics of medicinal cannabis plant extract (NTI164) treatment of paediatric acute-onset neuropsychiatric syndrome

ABSTRACT: Paediatric acute-onset neuropsychiatric Syndrome (PANS) is a syndrome of infection-provoked abrupt-onset obsessive-compulsive disorder (OCD) or eating restriction. This open-label trial investigated the safety and efficacy of NTI164, a cannabis-derived medicinal formulation rich in cannabinoids (minimal tetrahydrocannabinol), at 20 mg/kg/day for 12 weeks in 14 children with chronic-relapsing PANS (mean 12.1 years, females 29%). Proteomics, phosphoproteomics, and other omics approaches revealed baseline dysregulation of multiple signalling pathways in PANS versus controls that were significantly modified following NTI164 treatment.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Obsessive-compulsive Disorder

SUBMITTER: Mark Graham

LAB HEAD: Russell Dale

PROVIDER: PXD064184 | Pride | 2026-03-16

REPOSITORIES: Pride

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Medicinal cannabis plant extract (NTI164) modifies epigenetic, ribosomal, and immune pathways in paediatric acute-onset neuropsychiatric syndrome.

Keating Brooke A BA Han Velda X VX Nishida Hiroya H Aryamanesh Nader N Marshall Lee L LL Gloss Brian S BS Lau Xianzhong X Dissanayake Ruwani R Dervish Suat S Graham Mark E ME Mohammad Shekeeb S SS Kanhangad Manoj M Fahey Michael C MC Patel Shrujna S Dale Russell C RC

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20260108

Paediatric acute-onset neuropsychiatric syndrome (PANS) is a syndrome of infection-provoked abrupt-onset obsessive-compulsive disorder (OCD) or eating restriction. Based on the hypothesis that PANS is an epigenetic disorder of immune and brain function, a full-spectrum medicinal cannabinoid-rich low-THC cannabis (NTI164) was selected for its known epigenetic and immunomodulatory properties. This open-label trial of 14 children with chronic-relapsing PANS (mean age 12·1 years; range 4-17; 71 % ma ...[more]

PMID: 41513541

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			Action	DRS
	Deamidation_NQ_Sites.txt	Txt
	HomoSapiens20240304CanIso.fasta	Fasta
	NonPhos-f32-37.raw	Raw
	NonPhos-f38.raw	Raw
	NonPhos-f39.raw	Raw