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Utilizing a bioartificial 3D bronchial epithelial airway model to study lunar hay fever on Earth

ABSTRACT: This study underscores the urgent need to understand how lunar regolith dust affects human health, an issue critical for sustaining long-term human presence on the Moon. Past Apollo missions, revealed that lunar dust exposure can trigger allergy-like symptoms, suggesting a biological reactivity that is still poorly understood. Using a 3D human airway model that closely mimics real bronchial tissue, researchers found that lunar regolith simulant (JSC-1) causes unique and early physiological changes that differ significantly from responses to Earth-based dust (PM10). The distinct effects of lunar regolith on mucociliary clearance, barrier integrity, and airway remodeling suggest that cellular and molecular pathways are being activated or suppressed in ways not seen with terrestrial particles. Proteomics can uncover which specific proteins are altered during exposure, providing insight into the mechanisms of toxicity, stress response, and long-term adaptation or damage. Moreover, the data reinforces that terrestrial dust studies are not directly translatable to the lunar context. Therefore, proteomic profiling specific to lunar dust exposure is not just beneficial, it's necessary to develop targeted medical countermeasures, design safer habitats, and support the health of future lunar explorers.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bronchial Epithelial Cell Line

SUBMITTER: Patrick Hellwig

LAB HEAD: Marcus Krüger

PROVIDER: PXD064375 | Pride | 2026-04-10

REPOSITORIES: Pride

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			Action	DRS
	PC_ALI_medium_BD3_1_11449.d.zip	Other
	PC_ALI_medium_BD3_1_11449.mzBIN	Other
	PC_ALI_medium_BD3_1_11449_uncalibrated.mzML	Mzml
	PC_ALI_medium_BD3_1_11635.d.quant	Other
	PC_ALI_medium_BD3_1_11635.d.zip	Other

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