An early, novel arginine methylation of KCa3.1 attenuates subsequent T cell exhaustion.

ABSTRACT: We identified changes in the protein arginine methylome during the initial 30 min of TCR engagement and discovered a novel arginine methylation of a Ca2+ -activated potassium transporter, KCa3.1, which regulates Ca2+ -mediated NFAT1 signaling to ensure optimal activation.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cd8-positive

SUBMITTER: Suresh Poudel  

LAB HEAD: Douglas R. Green

PROVIDER: PXD064423 | Pride | 2025-05-29

REPOSITORIES: Pride