Deciphering Mutational Effects on Inducible Nitric Oxide Synthase Conformational Dynamics via Quantitative Cross-Linking Mass Spectrometry and AlphaFold2 Subsampling

ABSTRACT: In this project, we compare the abundancies of cross-links in wild type and mutant iNOSoxyFMN-CaM complexes at specific interdomain interacting site and map the identified sites onto top AlphaFold 2 models for better understanding of iNOS protein dynamics.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Ting Jiang  

LAB HEAD: Changjian Feng

PROVIDER: PXD064795 | Pride | 2025-10-30

REPOSITORIES: Pride