Ubiquitinomic data: Evolutionarily conserved E3 ubiquitin ligase modulates carotenoid, sterol and lipid crosstalk

ABSTRACT: After disrupting the E3 ligase PTR1 in Xanthophyllomyces dendrorhous CBS 6938 (Xd-ptr1), we observed a quadrupling of astaxanthin production, accompanied by increased levels of ergosterol and stellasterol. This disruption also resulted in a reduction of total lipids, a shift in fatty acid composition toward polyunsaturated species, and a decrease in triglyceride levels. To elucidate the mechanism by which PTR1 regulates carotenoid, sterol, and lipid metabolism, we conducted a ubiquitinomic analyse.

INSTRUMENT(S):

ORGANISM(S): Phaffia Rhodozyma

SUBMITTER: Ruilin Huang  

LAB HEAD: Shi'an Wang

PROVIDER: PXD065136 | Pride | 2026-04-09

REPOSITORIES: Pride